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| Section | Weight | Objectives |
|---|---|---|
| System-Based Standards and Population-Based Pharmacotherapy | 20% | - Population Health and Public Health
|
| Drug Information and Evidence-Based Medicine | 25% | - Literature Evaluation
|
| Patient-Centered Pharmacotherapy | 55% | - Monitoring and Follow-Up
|
1. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?
A) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
B) The sample size is inadequate to allow clinical conclusions.
C) Antihistamines should be administered to all children with otitis media who meet study entry criteria.
D) Chi-square is not the appropriate statistical test.
2. A 58-year-old man presents complaining of unsteady gait. Past medical history is significant for diabetes mellitus, gastroparesis, and depression. The patient exhibits a slight shuffling gait, mild limb rigidity, and decreased speed in performing rapid alternating movement. Current daily medications are bupropion, glyburide, metoclopramide, and omeprazole. Which of the following would be the most appropriate initial management for the presenting complaint?
A) Begin carbidopa/levodopa.
B) Discontinue bupropion.
C) Begin ropinirole.
D) Discontinue metoclopramide.
3. Which of the following disease states has been associated with stress-related mucosal bleeding and is an indication for initiation of stress ulcer prophylaxis?
A) Ulcerative Colitis
B) Coagulopathy
C) Diabetes mellitus
D) Gastric carcinoma
4. A clinical trial is being designed to evaluate the efficacy of an intermediate-acting niacin preparation in a population with regard to amelioration of coronary artery disease risk.
Bioethical considerations would restrict recruitment of subjects with poorly controlled diabetes mellitus, recent gastroduodenal ulcer disease, or hyperuricemia. Which principle would consider these patients to be ineligible for enrollment?
A) Beneficence
B) Equipoise
C) Justice
D) Autonomy
5. A 60-year-old man is admitted to the CCU with an acute anterior wall Ml. Therapy with amiodarone is initiated. The man's concurrent medications include Warfarin, furosemide, and enalapril. Which of the following baseline laboratory land clinical data, in addition to thyroid and liver function tests, should be obtained prior to initiation of amiodarone therapy in this patient?
A) Spirometry and 24-hour urine for creatinine clearance
B) FEV1 and baseline electroencephalogram
C) Chest X-ray
D) Fasting blood glucose
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: D | Question # 3 Answer: D | Question # 4 Answer: D | Question # 5 Answer: B |
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